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The Biomedical Entrepreneurship Skills Development Program for the Advancement of Research Translation: Foundations of Biomedical Startups course, metrics, and impact
- Part of
- Tucker Schweickart, Zachary Hill-Whilton, Sadhana Chitale, Daniel Cobos, Michal Gilon-Yanai, Joy Achuonjei, Gabriel Vizgan, Colleen Gillespie, Gabrielle Gold-von Simson
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue 1 / 2023
- Published online by Cambridge University Press:
- 27 February 2023, e77
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Background/Objective:
A growing number of biomedical doctoral graduates are entering the biotechnology and industry workforce, though most lack training in business practice. Entrepreneurs can benefit from venture creation and commercialization training that is largely absent from standard biomedical educational curricula. The NYU Biomedical Entrepreneurship Educational Program (BEEP) seeks to fill this training gap to prepare and motivate biomedical entrepreneurs to develop an entrepreneurial skill set, thus accelerating the pace of innovation in technology and business ventures.
Methods:The NYU BEEP Model was developed and implemented with funding from NIDDK and NCATS. The program consists of a core introductory course, topic-based interdisciplinary workshops, venture challenges, on-line modules, and mentorship from experts. Here, we evaluate the efficacy of the core, introductory course, “Foundations of Biomedical Startups,” through the use of pre/post-course surveys and free-response answers.
Results:After 2 years, 153 participants (26% doctoral students, 23% post-doctoral PhDs, 20% faculty, 16% research staff, 15% other) have completed the course. Evaluation data show self-assessed knowledge gain in all domains. The percentage of students rating themselves as either “competent” or “on the way to being an expert” in all areas was significantly higher post-course (P < 0.05). In each content area, the percentages of participants rating themselves as “very interested” increased post-course. 95% of those surveyed reported the course met its objectives, and 95% reported a higher likelihood of pursuing commercialization of discoveries post-course.
Conclusion:NYU BEEP can serve as a model to develop similar curricula/programs to enhance entrepreneurial activity of early-stage researchers.
5 - Contracts: parties and terms
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp 104-125
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Summary
This chapter explores two key concepts in contract law. First, it identifies the parties to a contract and the rules that help in that process. In particular, the doctrines of privity and agency, which assist with determining who incurs rights and obligations under a contract, are discussed. Second, the chapter considers the terms of a contract, including how to identify, incorporate and interpret them. Specific attention is paid to the various types of contract terms and how they should be interpreted.
Glossary
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp 480-501
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Copyright page
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp iv-iv
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Contemporary Australian Business Law
- Mark Giancaspro, Gabrielle Golding, Beth Nosworthy, David Brown, Jessica Viven-Wilksch, Alexandra Wawryk, Sylvia Villios, Paula Zito
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- 14 February 2023
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- 14 February 2023
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Australian businesses operate within a complex legal environment, so it's important students and professionals understand their legal obligations. Contemporary Australian Business Law is an authoritative text that makes key legal concepts accessible to business students, while maintaining academic rigour. Written for business students new to studying business law, this text introduces the fundamental legal topics encountered in business, including contracts, business structures, taxation, property and employment. Discussion in each chapter strikes a balance between accessibility and detail to assist understanding of these complex legal issues. A hypothetical scenario running through each chapter scaffolds learning and provides relevant real-world examples of the law in practice. Each chapter includes margin definitions, case boxes that guide students through landmark business law cases, and practice problems that test students' ability to apply their knowledge to realistic situations. Written by experts, Contemporary Australian Business Law is an essential introduction to the Australian legal system for business students.
Table of statutes
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp xxxiii-li
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6 - Contracts: performance and remedies
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp 126-149
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Summary
This chapter focuses on what occurs when a contract is performed and brought to an end. It discusses the rules regarding performance, termination, and the resulting remedies available in the event of a breach of contract. The concepts covered in this chapter are of vital importance to contracting parties. For instance, parties may wish to know how to fulfil their contractual obligations in order to bring a contract to a natural end. Conversely, they may want to know how to get out of a contract altogether, potentially ending it early, resulting in a breach. Assessing the various remedies that are available in the event of a breach of contract will therefore assist parties in shaping their interactions with one another, as well as protect them where they are the subject of a breach.
Contents
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp v-xiv
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8 - Employment law
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp 180-196
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Summary
Work is a universal human experience, making it highly applicable and interesting to study in a legal context. This chapter considers Australia’s workplace relations system, providing an overview of the complex framework of regulation, which differs between occupations and industries and, in some instances, between the federal and state/territory levels. It begins by considering the main sources of Australia’s employment law; operation of the Fair Work Act 2009 (Cth); the Fair Work Commission; the Fair Work Ombudsman; the National Employment Standards; Modern Awards and enterprise agreements; employment contracts; and the distinction between employees and independent contractors. Finally, it assesses how the various duties imposed by Australia’s workplace relations system can be enforced through an application for unfair dismissal.
Index
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp 502-513
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About the authors
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp xv-xvi
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Acknowledgement of Country
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp ii-ii
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Table of cases
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp xviii-xxxii
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Acknowledgements
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp xvii-xvii
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Abbreviations
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp lii-liv
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3 - Contracts: formation
- Mark Giancaspro, University of Adelaide, Gabrielle Golding, University of Adelaide, Beth Nosworthy, University of Adelaide, David Brown, University of Adelaide, Jessica Viven-Wilksch, University of Adelaide, Alexandra Wawryk, University of Adelaide, Sylvia Villios, University of Adelaide, Paula Zito, University of South Australia
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- Contemporary Australian Business Law
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- 14 February 2023
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- 14 February 2023, pp 54-70
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Summary
In our day-to-day living, we make contracts all the time, whether or not we realise we are doing so. The simple act of buying a new book, purchasing a cup of coffee, or requesting an Uber ride each requires the formation of a contractual agreement. Whenever you buy something or agree to pay money for a service, you are making a contract, whether you sign a written agreement or not. This chapter provides an overview of how contracts are formed in Australia. A contract, generally speaking, is a legally enforceable agreement on a set of promises. The chapter begins by explaining the importance of entering into contractual relationships for individuals and businesses alike. Australia’s sources of contract law are identified. The chapter then examines each of the key elements required in order for a valid and binding contract to be formed. Next, it considers the equitable doctrine of promissory estoppel, which operates to protect parties in the event that one or more of the requisite elements of formation of a contract is missing. Finally, the chapter examines the impact of technology on the formation of contracts.
2488 Parental perspectives on factors affecting participation in family centered rounds: Impact of technology use in trainee presentations
- Alexander Glick, Gabrielle Gold-von Simson, Michael Goonan, Diana Sandmeyer
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- Journal:
- Journal of Clinical and Translational Science / Volume 2 / Issue S1 / June 2018
- Published online by Cambridge University Press:
- 21 November 2018, pp. 71-72
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OBJECTIVES/SPECIFIC AIMS: Family centered rounding on pediatric inpatient units improves communication and family satisfaction. While the use of electronic medical record based devices and resources as part of the rounding process allows for immediate access of information and real time order management, there is limited data concerning parental perspectives’ about technology use on rounds, and about factors affecting participation during family centered rounds more generally. Our objectives were to examine parental (1) perspectives on factors that affect their participation during family centered rounds and (2) resource preference (tablet, computer on wheels, paper notes) used by trainees and the reasons for said preference. METHODS/STUDY POPULATION: We performed a cross-sectional study with English-speaking parents who were present for multidisciplinary family centered rounds and whose children were admitted to the inpatient pediatric unit at a tertiary care academic medical center. Parents were surveyed after rounds to ascertain their opinions on factors affecting their participation in rounds, preferences in respect to the resource used by trainee, and whether they believed the resource used on rounds that day affected their understanding or participation in rounds. Parents were also asked to articulate the reasons behind their preferred resource. Responses were analyzed using descriptive statistics, and qualitative responses were analyzed for themes. RESULTS/ANTICIPATED RESULTS: In total, 40 parents enrolled. Common responses regarding factors affecting parental participation included: information was explained in way that was easy to understand (90%), parents’ understanding of the medical information (85%), eye contact with the medical team (78%), if the medical team asks for parent input (75%), and the health of the child (70%). Fewer parents (23%) believed that the type of resource used affected their participation. Tablets were the preferred technology resource (33%) due to their portability, ease of accessing information, and that they encouraged interaction with the patient. Fewer preferred computers on wheels (27%) and paper notes (5%). In total, 35% of parents reported no preferred resource. No parents said that tablets were their least preferred resource. Reasons computers on wheels were least preferred (13% of parents) included their large size and that they limited eye contact, whereas, parents stated that paper notes were least preferred (13% of parents) because they were old-fashioned, easy to lose, and not accurate; 68% of parents stated the resource used did not affect their understanding on rounds that day, and 83% asserted the resource had no effect on participation. DISCUSSION/SIGNIFICANCE OF IMPACT: Clear and engaging communication during family centered rounds is most important to parents’ participation. The type of technology resource used is less relevant, but parents favor the use of tablets when they report a preference. Given the convenience for providers, tablet utilization as part of a family centered, trainee based rounding process has potential benefit.
The Hospital Anxiety and Depression Scale: low sensitivity for depression screening in demented and non-demented hospitalized elderly
- Nikolaos Samaras, François R. Herrmann, Dimitrios Samaras, Pierre-Olivier Lang, Alessandra Canuto, Alexandre Forster, Henriette Hilleret, Gabriel Gold
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- Journal:
- International Psychogeriatrics / Volume 25 / Issue 1 / January 2013
- Published online by Cambridge University Press:
- 13 September 2012, pp. 82-87
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Background: We currently use the depression subscale (HADD) of the Hospital Anxiety and Depression Scale (HADS) for depression screening in elderly inpatients. Given recent concerns about the performance of the HADD in this age group, we performed a quality-control study retrospectively comparing HADD with the diagnosis of depression by a psychiatrist. We also studied the effect of dementia on the scale's performance.
Methods: HADS produces two 7-item subscales assessing depression or anxiety. The HADD was administered by a neuropsychologist. As “gold standard” we considered the psychiatrist's diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria. Patients older than 65 years, assessed by both the HADD and the psychiatrist, with a clinical dementia rating (CDR) score lower than 3, were included. The effect of dementia was assessed by forming three groups according to the CDR score (CDR0–0.5, CDR1, and CDR2). Simple and multiple logistic regression models were applied to predict the psychiatrist's depression diagnosis from HADD scores. Areas under the receiver operating characteristics curve (AUC) were plotted and compared by χ2 tests.
Results: On both univariate and multiple analyses, HADD predicted depression diagnosis but performed poorly (univariate: p = 0.009, AUC = 0.60 (95% confidence interval (CI) = 0.53–0.66); multiple: p = 0.007, AUC = 0.65 (95% CI = 0.58–0.71)), regardless of cognitive status. Because mood could have changed between the two assessments (they occurred at different points of the hospital stay), the multiple analyses were repeated after limiting time interval at 28, 21, and 14 days. No major improvements were noted.
Conclusion: The HADD performed poorly in elderly inpatients regardless of cognitive status. It cannot be recommended in this population for depression screening without further study.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
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A prospective high-risk study of the association among maternal negativity, apparent frontal lobe dysfunction, and the development of bipolar disorder
- STEPHANIE E. MEYER, GABRIELLE A. CARLSON, EDYTHE A. WIGGS, DONNA S. RONSAVILLE, PEDRO E. MARTINEZ, BONNIE KLIMES-DOUGAN, PHILIP W. GOLD, MARIAN RADKE-YARROW
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- Development and Psychopathology / Volume 18 / Issue 2 / June 2006
- Published online by Cambridge University Press:
- 28 March 2006, pp. 573-589
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In a previous paper, the authors found that impairment on the Wisconsin Card Sorting Test (WCST) in adolescence was predictive of bipolar disorder in young adulthood among offspring of mothers with bipolar illness. In the present study, the authors explore the contribution of maternal characteristics, beyond maternal mood disorder, to the prediction of offspring dysfunction on the WCST. Results showed that maternal bipolar disorder and maternal negativity were both predictive of impaired performance on the WCST during adolescence. The contribution of maternal negativity to offspring WCST impairment was not better explained by maternal personality disorder, mother's functional impairment, family loading for bipolar disorder, or offspring disruptive behavioral disturbance. Findings did not support a moderator model. However, support was found for a mediation model in which maternal negativity contributed to risk for offspring bipolar disorder through its negative association with apparent frontal lobe functioning, as measured by the WCST. Findings are discussed from the perspective of a vulnerability–stress model. In addition, the authors consider the possibility that maternal negativity and offspring impairment on the WCST may be reflective of a common heritable trait.
The findings presented in this paper come from the doctoral dissertation of the first author, which was funded by an NIMH Intramural Research Training Award. The authors are enormously grateful to Anne Mayfield, without whom this project would not have been possible. We are deeply indebted to Ann S. Masten, W. Andrew Collins, L. Alan Sroufe, Monica Luciana, and Carrie Borchardt, who provided support and guidance throughout all stages of this project. We are also thankful to Robert Asarnow for his advice and encouragement, and to Roger E. Meyer and Daniel N. Klein for their comments on earlier drafts of this paper. In addition, we acknowledge the contributions of Gail Inoff-Germain, who administered diagnostic interviews and neuropsychological measures at adolescent follow-up; Rula B. Garside, who undertook the painstaking job of establishing interrater reliability; Erika Sundstrom, who devoted many hours to data organization and quality assurance; and Sara Avery Torvik and Patricia Kasdan, whose combined gifts of organization and warmth created a comfortable atmosphere for study participants. Finally, we thank the extraordinary research participants of the NIMH Childrearing Study, who have shown enormous bravery and dedication by sharing with us 23 years of their lives.